gwyg
1 post
Apr 10, 2009
5:00 PM
|
Does this mean that the drug is not working for me? or could it be too much?
I have symptoms of freezing and stiffness but no tremors. when I take the drug, I can move so much more freely...arm swing is back. less foot drag, more momentum but the accompanying extra movements I could do without.
Suggestions?
|
ThePharmacist
248 posts
Apr 10, 2009
9:02 PM
|
too much sinemt can cause dyskensia. It puts many of us in a bad situation. The higher dose takes care of many symptoms but can cause dyskensia, which is horrible in itself. There are a few things you could try. You could talk to your dr about sinemet cr, which is a longer acting sinemet which could cause less dyskensia. Another option may be a product called stalevo. This medication combines sinemet with entacapone ( which helps the sinemet work longer). These may be a few options that you could discuss with your dr if the dyskensia gets to be too much on you. Best of health, Mark
|
Brenda
25 posts
Jul 02, 2009
7:56 PM
|
I have the same problem-any new rx we could ask dr to try?
|
Beccapooh
108 posts
Jul 03, 2009
2:40 PM
|
I just started taking 25/100 of Sinemet 3 times a day and it seems to be making me feel much better. What I do, do however, that might be different from what y'all do, is...I also take Sinemet 10/100 in between my doses of 25/100. So I take my meds 6 times a day now and that seems to be working the best for me. I take it 25/100 when I wake up, then 4 hours later I take a 10/100 and then four hours later another 25/100, and so on. This has worked wonders for me!!!
|
brooksie
38 posts
Jul 05, 2009
6:11 PM
|
Beccapooh, I'm currently considering monotherapy with Sinemet as Mirapex seems to be a lot of nothing for me. I take Sinemet 25/100 throughout the day. How does taking the 10/100 in between help? Is the 25/100 dose too much for your system every four hours? TIA Laura
|
Beccapooh
119 posts
Jul 07, 2009
8:06 AM
|
It's been an "adventure" trying to find the right dosage at the right time, etc. For me, personally, I WAS taking (originally) just the 10/100's. I was taking 1 of them 3 times a day. That did NOTHING. So we starting increasing it by one table per day until I was up to taking two 10/100's 3 times a day. That was "better" but not great, so my doc ordered the 25/100's and told me to add those in, one at a time, to replace ONE of the 10/100's, i.e. I'd be taking one 10/100 and one 25/100 three times a day. Well, that DOES work, but, I still find that A) I end up feeling more nauseous, B) I "FEEL" the meds kicking in and don't like that "PEAK DOSE" feeling and C) I was still having the wearing "OFF" effect at the end of the 8 hours (after about 5-6 hours, I just felt bad...). So, taking all of that into account, we decided (well, I decided) to take less of them at a time and more often. Like magic....It's the combination that works for me. I've heard that it's really an "art", getting these meds right and less of a science. Good luck and I hope that this helped. Bec PS- I also found that taking the two 10/100's made me feel more "drugged up" and "sleepy". I don't feel that way on this routine.
|
brooksie
40 posts
Jul 07, 2009
10:09 AM
|
I'm asking because I find that Sinemet 25/100 doses work the best for me. I reintroduced Mirapex 9 weeks ago and it seems to be doing nothing other than some icky side effects. Weird because last year before I had my baby, I was doing okay on Mirapex and Sinemet. Now, I have to take Sinemet like every two hours! Sad, but true. Have you thought of trying the Sinemet CR? It's supposed to provide a steadier flow of meds, so you'd have little "peak dose" sensation I would think.
|
Beccapooh
121 posts
Jul 07, 2009
10:52 AM
|
When I go to see the MDS, I'm going to ask for that. Right now, my PCP is the one doing the script writing and I don't think he knows much about the CR version. Is that one more expensive, does anybody know?
|
Bonster
10 posts
Jul 11, 2009
5:16 PM
|
Hi.....I pay almost double for the CR version (in Canada). I take 4 Sinemet CR 200/50 a day and 3 Sinemet 100/25 a day. Unfortunately, I don't think either of them are working for me -- I don't have any off/on times. If I miss taking a pill or am late, nothing's different ... my neuro just keeps increasing the dosage -- I asked her when will I know if there working....I have some freezing, a little stiffness when standing up, but mostly sore back and poor posture, no tremors ...I'd love to take a drug that would deal with these issues. I guess thats the waiting game with P.D.
|
brooksie
48 posts
Jul 12, 2009
5:59 AM
|
Hi Bonster, Maybe try posting your message in the Pharmacist's Forum? Mark may have some suggestions as to what will help with stiffness and rigidity. I thought that Sinemet helped primarily with tremor and rigidity- maybe you want a second opinion on that PD diagnosis? A trial of Levodopa is often used to confirm it, and if it's not working for you...maybe you should consult another MDS just to be sure.
|
ThePharmacist
307 posts
Jul 20, 2009
7:32 AM
|
As we know, pd effects many parts of our body. The muscle rigidity and stiffness may not be taken care of by sinemet alone. I have seen that baclofen or tizanidine work well to relax the muscles and decrease rigidity and stiffness. These 2 muscle relaxers work differently than others because they work from the spinal cord out. Other muscle relaxers work in the brain and can cause excess drowsinass. Ask your dr about these meds and see if it may be a good option for you. Both are comparable with other pd meds. Best of health, Mark
|
ThePharmacist
308 posts
Jul 20, 2009
7:33 AM
|
As we know, pd effects many parts of our body. The muscle rigidity and stiffness may not be taken care of by sinemet alone. I have seen that baclofen or tizanidine work well to relax the muscles and decrease rigidity and stiffness. These 2 muscle relaxers work differently than others because they work from the spinal cord out. Other muscle relaxers work in the brain and can cause excess drowsinass. Ask your dr about these meds and see if it may be a good option for you. Both are comparable with other pd meds. Best of health, Mark
|
