I noticed the other day, that certain PD symptoms dominate at different times during a wear off, and that these symptoms can change in the course of a few weeks. A month ago, it was right side rigidity that took center stage at wear off time, and now it's a weird pressure sensation in my head that causes a sort of vertigo. Several months ago, I would experience slowness as my primary wearing off "treat". Tremor has been a constant companion, but interestingly, it is also the first PD symptom I presented.

I'm wondering...how this revolving door of symptoms are related or not? Why do certain symptoms surface at one time only to be replaced by another a few weeks later? I first thought it was due to disease progression, but my PD traits that pop out between meds seem to re-circulate, not change permanently. Some early symptoms I had resurface on rare occasion, like foot drag, but my handwriting in general has declined and remains that way. Do you think it's just that meds tend to mask some symptoms better than others and that this changes due to who knows what? I have recently re-introduced Mirapex and Azilect to my Sinemet therapy; I noticed very different emergent symptoms when on only Sinemet.

Does anyone else experience this? It's frustrating because I then never know what to expect and this, as you know, just adds to the stress level we all feel regarding our health.

Best,

Laura

Last Edited on 29-Jun-2009 2:24 AM

In short the answer is a resounding YES. Check my post - PLEASE HELP - NEW SYMPTOMS - and read the answers and in particular the answer from "gman". PD proves, it seems to me, to be varied and unpredictable. I know too the stress this causes. When something new pops up it's like "Ok, another symptom. What's next?"

The other question, disease progression or meds masking, well that too is accurate. The disease progresses period and the meds will help. Some better, some worse. Some longer, some not as much.

Lastly, I have learned myself to not be surprised when symptoms new or not occur, disappear, or wax and wane. It seems to be the nature of the disease.

As always, other feel free to correct me or to add.

Thanks,

John Noland